Endocrine Abstracts

The pharmacologic armamentarium available to clinicians to reduce fracture risk in women with postmenopausal osteoporosis consists essentially of antiresorptive agent. Recently, peptides from the parathyroid hormone (PTH) family, which under specific modalities of administration act as anabolic agents have become available. The interest generated by these alternatives to antiresorptive treatment resides in their greater potential for restauration of bone mass and possibly also...

ContextSevere hypothyroidism and Systemic Lupus Erythematosus can both be causes for the development of pericarditis with concomitant pericardial effusion.Case illustrationWe report the case of a 23 year-old woman admitted in the ER for progressive dyspnoea, increasing fatigue and peripheral edema, associated with hepatosplenomegaly and polyadenopathy. Transthoracic echocardiogram confirmed sever...

Background: Pancreatic neuroendocrine neoplasms (NENs) are rare tumors which can sometimes be diagnosed based on symptoms of hormone excess, but, more often, they are asymptomatic, and patients frequently present with metastatic disease. While they can occur in hereditary cancer syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau (VHL), or neurofibromatosis (NF1), the majority of pancreatic NENs are sporadicCase report: We rep...

Introduction: Resistance to thyroid hormones (RTH) is a rare syndrome. This condition is caused by gene mutations of thyroid hormone receptors (THR). There are two types of genes that code THR: THR alpha (THRA) and THR beta (THRB). The RTH alpha is associated with mutations in the THRA gene and is less common than RTH beta [1]. It is challenging to identify patients with RTH alpha because usually they only have mildly abnormal (or even normal) thyroid hormone levels and the se...

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...

We evaluated 341 postmenopausal women, aged 29–84 years (mean age 58.18±9.01) and referred to the Center for Osteoporosis starting December 2013. Secondary causes of osteoporosis/bone loss and patients under antiosteoporotic medication or under vitamin D substitution were excluded from the study. All patients performed DXA measurement (Dexxum T, Osteosys, Inc., South Korea) (same expert). FRAX and 25 HO vitamin D levels were determined. We defined vitamin D deficienc...

Objectives: The cases described in the literature, with postpartum and lactation osteoporosis, are very rare.Material: A case report: 28 years old women, that give birth to a 3250 g weight term child, APGAR 10, breast feeding period: 3 months, with acute back pain starting the 2nd months after delivery. On the moment our evaluation she resumed breastfeeding.3 months after delivery she came in our office with diagnosed acut...

Objectives: We evaluated the diagnostic power of different used evaluation criteria in ultrasound 2B, Doppler and elastography.Method: Retrospective data analyses of all cases with breast lumps, that were evaluated and also operated during the study follow-up period. Study period: January 2011–April 2013 (Table 1).Ductal breast ultrasound, Doppler and real-time elastography was performed with a HITACHI EUB 7500 HV machine, wit...

Introduction: The study aimed to analyze the efficiency of a concomitant N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac high-sensitivity troponin T (hs-cTnT) testing in diagnosing non-ST-segment-elevation myocardial infarction (NSTEMI) in patients initially negative for the standard fourth-generation assay of cardiac troponin T (cTnT), but with high clinical probability of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS).Meth...

Introduction: Sox2 is a widely expressed marker of progenitor and stem cells in various organs, strongly expressed within Rathke’s pouch and the neural ectoderm. It exerts a critical role in the early stages of pituitary development but it is still expressed in the adult gland. Sox2 expression in pituitary adenomas and its possible correlation with clinicopathologic characteristics have not been investigated so far.Aim: To evaluate the immunohistoch...